The Science Behind NAD+

Researchers gave 25 women with prediabetes a daily NMN supplement for 10 weeks. By the end, their muscles were much better at responding to insulin — meaning cells could take in sugar more efficiently. Think of it like oiling a stuck door: the muscles started working the way they were supposed to. This matters because poor insulin response is linked to fatigue, weight gain, and faster aging.

Forty-eight amateur runners were split into groups: some got NMN, some got a placebo. After six weeks, the NMN group could run longer before exhaustion, used oxygen more efficiently, and had lower heart rates at the same running speeds. Basically, their bodies were working smarter — getting more out of each breath. Higher doses produced stronger results.

One of the largest human NMN trials to date. Over 100 healthy older men took NMN daily for 12 weeks. Blood tests confirmed their NAD+ levels went up significantly — and stayed up. On top of that, their grip strength and walking speed improved compared to the placebo group. This is important because muscle loss and NAD+ decline happen together as we age, and this study showed you can slow both at once.

This large, well-designed trial tested two different NMN doses in 80 healthy adults between the ages of 40 and 65. Both doses raised NAD+ levels in the blood within weeks. The higher dose (600mg) also improved physical performance scores, reduced fatigue, and improved sleep quality ratings. Importantly, blood work, liver enzymes, and vital signs all came back normal — confirming NMN is safe for daily use.

Published in one of the most respected medical journals in the world. Researchers gave NMN to overweight and obese adults aged 45–65 for 12 weeks. By the end, the NMN group could walk faster on a standardized test, had better muscle quality on MRI scans, and lost more weight compared to placebo. The researchers concluded that NMN improves how well your muscles use energy — which matters for everyone, not just those trying to lose weight.